Scientist I - D3B Center

Philadelphia, PA, US, 19104

Job Type: 

COLKET - Colket Translational Research Req ID: 28503

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

The Center for Data Driven Discovery in Biomedicine (D³b) is a transformative healthcare discovery ecosystem at Children’s Hospital of Philadelphia (CHOP) Research Institute, one of the largest pediatric research institutes in the U.S.


D3b’s multi-disciplinary team brings together experts in basic science, precision medicine, bioinformatics and genomic research to provide innovative and personalized care for children through collaborative, data-driven science. Under its “open-science” model, the center drives the secure generation and integration of complex genomic and clinical patient data, and develops the open-access platforms that support collaborative discovery. Researchers worldwide are able to access this information and work together to fully empower and share novel approaches to biological targets for precise, less toxic clinical treatments on behalf of children.



D3b center is looking for a Research Scientist to support its translational research and data driven laboratory projects. The candidate will be responsible for the development of patient tumor derived research models (cell lines, patient derived xenografts, organoids) and pursuing biomarker discovery research in the preclinical research unit. The person will work in Dr. Resnick’s laboratory under the mentorship of the laboratory director Dr. Mateusz Koptyra. We are looking for a dedicated person who will support all aspects of the pediatric brain tumor biomarker explorations efforts; from sample processing and model generation through data generation and analysis to the basic research validation studies.  The selected candidate will work closely with the principal investigator and support project strategy providing scientific expertise from the ground up and guiding the function of the research unit.



- Assists the laboratory director in conducting research of significant value in basic and/or translational science projects
-  Supports hands-on and helps to manage the effort for the generation of specimen derived research models
- Develops scientific questions around the center’s projects and executes the hypothesis by conducting the wet bench research work
- Reviews raw and computed data from DNA/RNA/proteomic profiling; designs and executes the validation studies
- Collaborates with bioinformatics team, fellow researchers, and external institutions to develop cooperative research initiatives
-  Performs and documents experiments in a rigorous and reproducible manner
-  Collects, analyzes and presents data at both internal and external meetings
- Trains and/or manages the technical staff and students in lab procedures and project pipelines
-  Generates and reviews manuscripts for peer-reviewed journals
- Assists in composing/developing applications for grants/contracts for funding of research projects
-  Promotes free discussion, research progress, and overall morale

Job Responsibilities
  • Conducts research of significant scientific value in the basic and/or translational science area(s) relevant to their practice specialty.
  • Participates in the design, planning and conduct of one or more experiments.
  • Trains technical staff, students, fellows & physicians in lab procedures.
  • Monitors daily resource allocations and day-to-day lab personnel activities.
  • Composes/Assists in developing publications for peer reviewed, scientific, quality and management, Journals.
  • Assists with the submission of applications for grants/contracts for funding of research projects.
  • Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives.
  • Responsible for appropriate use of research funds.
  • May supervise technical staff and students.
  • May participate in educational programs and teaching assignments.
Required Education and Experience

Required Education: Terminal degree (MD, PhD, DVM) required. Can be substituted for Masters of Science with 6-8 years of scientifically relevant experience. 


Required Experience: 0-2 years of scientifically relevant post-fellowship experience.

Preferred Education, Experience & Cert/Lic

Preferred Experience: Post-Doctoral fellowship experience.

-       PhD in life sciences (oncology, immunology, pathology, molecular biology, cell biology or a related field), 1-3 years post-doctoral experience or scientifically relevant experience preferred
-       Proficiency in cell culture, basic cell analysis methods and animal work is required
-       Previous experience with development of specimen derived research models is a plus
-       Experience with high throughput data generation techniques (WGS, RNAseq, methylation profiling) is a plus
-       Previous experience with development of specimen derived research models is preferred
-       Experience in the analysis of large datasets is preferred
-       Previous experience with biomarker discovery and validation process is a plus
-       Demonstrable experience with record keeping and quality measures is required
-       Technical proficiency, ability to learn new techniques quickly, effective problem solving and critical thinking skills required
-       Previous experience with Microsoft Excel in data formatting is required
-       Knowledge of biostatistics is a plus
-       Ability to work in a team environment and consistently meet deadlines.
-       Excellent communication, interpersonal and organizational skills.

Additional Technical Requirements
  • 100% of effort is funded by Principal Investigator(s) grants


All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288




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