Scientist I-CAR T cell-based Cancer Immunotherapies- Maris Lab

Philadelphia, PA, US, 19104

Location: LOC_COLKET-Colket Translational Research 

Req ID: 148793

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

We are seeking a highly motivated Scientist to perform various functions within a growing team focused on the development of immunotherapies for pediatric cancers with high unmet needs. The scientist will join a dynamic multidisciplinary group focused on developing novel CAR T cells involving all stages of the immunotherapy development pipeline: target discovery, CAR engineering, optimization, preclinical testing, and clinical development.

The scientist will be responsible for performing independent experiments, developing and optimizing assays, and collecting/analyzing/interpreting/presenting data. Scientist will be involved in a broad range of experimental approaches covering the entire developmental process of new immunotherapies. This work will build on a publication currently in press at Nature as well as focus on developing the next generation of cellular therapies.

The scientist will work as part of local and international multidisciplinary teams funded by Stand Up To Cancer and the Biden Cancer Moonshot initiatives, and will benefit from exposure to local and off-site expertise, collaborations, and scientific meetings.

Prior experience in immunological, biochemical and molecular biology techniques preferred. Techniques include, but are not limited to:  molecular biology, flow cytometry, cell culture, cloning and T cell transduction, immunological assays, protein engineering, mass spectrometry, and single-cell sequencing.

Scientist will participate in development of therapies intended for clinical translation. Individuals will have the opportunity to develop independent projects and execute them under direct supervision.

Preferred Education and Experience:

PhD in relevant field required, postdoc and/or industry experience preferred. Preference given to applicants with prior experience in any of the following: proteomics, molecular biology and immunology assays. Computational experience preferred but not required.

This work will build on the recent publication:


Job Responsibilities

  • Conducts research of significant scientific value in the basic and/or translational science area(s) relevant to their practice specialty.
  • Participates in the design, planning and conduct of one or more experiments.
  • Trains technical staff, students, fellows & physicians in lab procedures.
  • Monitors daily resource allocations and day-to-day lab personnel activities.
  • Composes/Assists in developing publications for peer reviewed, scientific, quality and management, Journals.
  • Assists with the submission of applications for grants/contracts for funding of research projects.
  • Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives.
  • Responsible for appropriate use of research funds.
  • May supervise technical staff and students.
  • May participate in educational programs and teaching assignments.

Required Licenses, Certifications, Registrations


Required Education and Experience

Required Education: Terminal degree (MD, PhD, DVM) required. Can be substituted for Masters of Science with 6-8 years of scientifically relevant experience. 


Required Experience: 0-2 years of scientifically relevant post-fellowship experience.

Preferred Education, Experience & Cert/Lic

Preferred Experience: Post-Doctoral fellowship experience.

Additional Technical Requirements

  • 100% of effort is funded by Principal Investigator(s) grants

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

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Talent Acquisition

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Philadelphia, PA 19146 




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