Research Tech IV-Center for Cellular and Molecular Therapeutics

Philadelphia, PA, US, 19104

Job Type: 

Req ID: 26241

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

A Research Technician IV is required for a young lab that combines technology development of pooled genome-wide CRISPR based perturbation screens, genome-editing and additional high throughput genomic approaches for studying early and late onset neurodegenerative diseases. The lab is part of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics (CCMT) and the Department of Genetics at the University of Pennsylvania (UPenn). The CCMT fosters a multidisciplinary approach among researchers and scientists working to discover new gene and cell therapies in search of cures for debilitating and life-threatening disorders.

Dr. Shalem was one of the pioneers in using CRISPR genome-editing technology for genome-wide pooled screens and continues to develop novel screening and high-throughput approaches for studying protein quality control pathways and disease mechanisms of neurodegeneration.

The successful applicant with work closely with Dr. Shalem and the lab team including graduate students and postdocs and will be an integral and essential part of the lab. She/He will receive training in a range of techniques including molecular biology, cell culture, cell biology, high-throughput screens, genome editing, stem cell and differentiation protocols, next generation sequencing and data analysis.

Previous experience in biological research is required. Candidates with some computational background including R, Python and unix would be preferred. Self-motivation, and a keen interest in learning new techniques is a must!

Job Responsibilities

Performs lab tests which require the analysis of results and interpretation of methods

Performs research procedures on experimental samples as directed

Assists with planning specific research protocols and procedures

Assists in development & troubleshooting of new techniques and ideas

Modifies methods and protocols (in conjunction with PI)

Formulates and performs complex lab experiments and analyzes & reports the data

Prepares laboratory reagents and monitors and maintains inventory

Performs calculations and maintains appropriate log books and lab notebooks

Presents & discusses work at weekly lab meetings and national symposia

Trains and mentors new staff as needed

Assists with determining work assignments, schedules and priorities

Assists in or prepares the writing of grants, journal articles, poster and oral presentations

Required Licenses, Certifications, Registrations


Required Education and Experience

Required Education: Bachelor’s Degree


Required Experience: Two (2) years of laboratory experience

Preferred Education, Experience & Cert/Lic

Preferred Education: Bachelor’s Degree


Preferred Experience:

  • Three (3) years of laboratory experience
  • Previous supervisory experience.

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288




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