Research Tech IV- Mitochondrial Research

Philadelphia, PA, US, 19104

Job Type: 

LOC_ABRAMSON-Abramson Building Req ID: 82865

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

Dr. Falk's research laboratory at The Children’s Hospital of Philadelphia Research Institute was established in 2006 and is focused in researching the mechanisms underlying disease, and potential novel therapies, for mitochondrial respiratory chain diseases. The laboratory primarily uses human cell, C. elegans (worm), zebrafish, small animal models, and occasionally mouse models for these purposes.

We have a position open immediately for a high level research technician to join the group to investigate the therapeutic mechanisms of primary mitochondrial disease through whole-animal behavioral phenotyping and mitochondrial physiology studies, as well as assisting in the evaluation of the efficacy and toxicity of pharmacologic agents in both cell and animal models of primary mitochondrial respiratory chain diseases.  This work involves analyses of candidate therapies and high-throughput drug screening, with both academic and pharma partners.     

Prior experience is highly desirable in performing translational investigations C. elegans, zebrafish, and/or human cell culture, working with pharmacologic agents, and standard molecular laboratory investigations including gene expression profiling, cell sorting analyses, gene sequencing, and western blot analyses.  Experience performing high-throughput drug screening in cells and animal models is strongly preferred.  Experience with mitochondrial models or physiology investigations and/or training in pharmacology is highly desirable.  The successful applicant will be a team player, work independently but with regular communication with the PI and study team, have strong data analysis skills including in Excel, Prism, ImageJ, and Matlab, excellent organization skills, be a quick learner, be highly attentive to detail, have excellent communication skills, and be able to make a 2 year commitment to this research program.

• Bachelor’s degree required
• Minimum 2 plus year relevant laboratory experience required.

Job Responsibilities

  • Independently performs advanced, complex research procedures on experimental samples
  • Formulates and performs complex lab experiments and analyzes reports the data including interpretation of methodologies
  • Performs advanced calculations and maintains appropriate log and lab notebooks
  • Plans and modifies research protocols and procedures with minimal direction from the principal investigator or supervisor
  • Assists in development & troubleshooting of new techniques and ideas
  • Prepares laboratory reagents, monitors and maintains laboratory inventory
  • Supervises, trains and mentors junior and new staff members
  • Determines work assignments, schedules and laboratory priorities
  • Presents & discusses work at weekly lab meetings and national symposia
  • Assists in writing of grants, journal articles, poster and oral presentations

Required Education and Experience

Required Education: Bachelor’s Degree


Required Experience: Two (2) years of laboratory experience

Preferred Education, Experience & Cert/Lic

Preferred Education: Bachelor’s Degree


Preferred Experience:

  • Three (3) years of laboratory experience
  • Previous supervisory experience.

Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 




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