Research Tech II

Philadelphia, PA, US, 19104

Job Type: 

Req ID: 23666

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

The Research Technician II will support the basic science components of the Myelin Disorders Biorepository Project (MDBP), an international patient registry that seeks to collect and analyze clinical data and biological samples from patients with suspected or confirmed leukodystrophies, a group of approximately 31 rare genetic disorders that affect development of the white matter of the brain, predominantly in pediatric populations. MDBP researchers are currently focused on uncovering novel genetic etiologies within this group of disorders, identifying key biomarkers, and developing a repository of natural history data to support therapeutic development.

The MDBP is the world’s largest leukodystrophy biorepository, having enrolled over 2,000 individuals affected with leukodystrophies. The study’s principal investigator, Dr. Adeline Vanderver, also serves as Program Director of the CHOP Leukodystrophy Center, which was established in 2015 with the mission of providing comprehensive clinical care, diagnostic testing and the most advanced treatments available to infants, children and adolescents with leukodystrophies and other white matter disorders.

The Research Technician II will work closely with senior researchers to support key functions of the biorepository, such as cell culture, mouse colony support, human tissue sample processing, and data management. This is a high-volume, fast-paced project, and a successful candidate must be able to demonstrate an ability to multi-task. Prior experience working or volunteering in a laboratory environment is required, and clinical research experience is preferred. Outstanding written and oral communication skills are essential, as the position involves collaboration with other researchers within the institution, as well as with other participating study sites.

This position is intended for individuals interested in a career in in the basic or health sciences, and a successful applicant must have a demonstrable passion for academic research, as well as a desire to make meaningful contributions to the rare disease field. The Vanderver Lab is a founding member of the Global Leukodystrophy Initiative (GLIA), an international consortium of clinicians, researchers, and disease advocates that seeks to build collaborative partnerships and will serve as a platform for industry-sponsored clinical trials.

Job Responsibilities

Cell Culture Support: Will involve dissection and isolation of primary cells from brain and spinal cord; handling, maintenance, and expansion of human induced pluripotent stem cells (iPSCs); support with differentiation of iPSCs into neural stem cells to further develop them into neuronal and glial lineage lines;
Mouse Colony Support: Breeding, identification, and genotyping and/or sequencing of various transgenic mouse colonies;
Human Tissue Sample Processing: Coordination of on-site and/or off-site human sample collection and shipping logistics, nucleic acid extraction from human tissue samples, isolation of peripheral blood mononuclear cells (PBMCs) from human blood samples;
Biorepository Management: Storage and organization of collected human samples using both REDCap- and Excel-based logging systems;
Research Administration: Preparation of manuscripts and poster presentations, attendance at regular laboratory meetings, general administrative support for senior research staff and principal investigator.

Required Education and Experience

  • Associate’s degree, 9 - 18 months laboratory experience required
  • Relevant Internship experience considered

Preferred Education, Experience & Cert/Lic

Bachelor’s Degree (B.S. or B.A.) in a relevant field of study;
At least (1) year of paid or unpaid experience in a laboratory environment;

Additional Technical Requirements

Previous experience with cell culture (inc. iPSC) approaches strongly preferred;

Previous experience with mouse colony management strongly preferred;

Previous experience with REDCap strongly preferred;  

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

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Talent Acquisition

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Philadelphia, PA 19146 

Phone: 866-820-9288




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