Research Tech II - Oncology

Philadelphia, PA, US, 19104

Job Type: 

LOC_COLKET-Colket Translational Research Req ID: 75521

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

The Research Technician II will have a BS or BA degree in the biological or chemical sciences or another scientific discipline and will conduct translational pediatric cancer and immuno-oncology research under the direction/guidance of Dr. Kris Bosse in collaboration with the St. Baldricks-Stand Up To Cancer Immunogenomics Team (https://standuptocancer.org/research/research-portfolio/dream-teams/high-risk-pediatric-cancers-dream-team/). Dr. Bosse’s laboratory is focused on developing immunotherapeutic strategies targeting tumor integral cell surfaces molecules in neuroblastoma and other incurable pediatric cancers (see Bosse et al., 2017 Cancer Cell as an example). There is also a major focus in the Bosse Laboratory on utilizing circulating tumor DNA (ctDNA) to define mechanisms of therapeutic resistance and disease progression in neuroblastoma. The research technician will join a growing translational research team based in his laboratory, and work in collaboration with several other laboratories at CHOP/Penn. Ongoing projects include translating current immunotherapies in the lab across pediatric cancers, new immunotherapeutic target discovery in neuroblastoma and other pediatric cancers, chimeric antigen receptor T cell therapy and antibody-drug conjugate development, defining mechanisms of tumor cell intrinsic and extrinsic immune escape, deciphering the key biologic functions of prioritized immunotherapeutic targets and using serial neuroblastoma preclinical models to define mechansisms of therapeutic resistance. Diverse molecular biology, genomic, and in vitro and in vivo laboratory techniques will be employed.  

The ideal candidate will (1) Work independently and be self-directed with guidance from the principal investigator, (2) Develop new experimental procedures and hypotheses for further investigation and will help the principle investigator publish and present research results, (3) Assist with the management of laboratory operations, (4) Collaborate and interact with other researchers within the laboratory, institution and at other institutions, (5) Consistently exercise discretion and judgment in execution, interpretation of experiments, and of data derived, and (6) Have some laboratory experience with techniques such as cell culture, RNA purification, PCR, cloning, Western blotting, in vitro functional assays, and flow cytometry. Experience working with mouse models would also be a plus. At least a 2-year commitment is required. Will have multiple opportunities to present work at national and international meetings and will be involved in writing manuscripts. Laboratory environment includes a diverse range of scientists and trainees at all career levels, including multiple research technicians doing a 2-3 year laboratory experience prior to applying to professional (e.g. Graduate or Medical) school.      

Job Responsibilities
  • Performs routine tests under the direction of principal investigator or supervisor
  • Performs research procedures on experimental samples as directed
  • Records and checks results for completeness and accuracy
  • Performs calculations and maintains appropriate log and lab notebooks
  • Performs tasks that require familiarity with fundamental techniques and equipment
  • Assists with planning specific research protocols and procedures
  • Maintains office, lab area, reagents, supplies and equipment
  • Cleans and performs routine maintenance on lab equipment
  • Coordinates schedules of tests & procedures
  • Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
  • Records results, organizes data and maintains lab notebook in an organized manner
  • Conducts literary searches as directed
Required Education and Experience

Required Education: Associates Degree or active enrollment in a Bachelor’s Degree Program


Required Experience: Nine (9) months of laboratory experience

Preferred Education, Experience & Cert/Lic

Preferred Education: Bachelor’s Degree


Preferred Experience:

  • Eighteen (18) months of laboratory experience
  • Related internship experience.



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Philadelphia, PA 19146