Research Postdoctoral Fellow (Leukodystrophy Center)

Philadelphia, PA, US, 19104

​Location: LOC_ABRAMSON-Abramson Building 

Req ID: 225296

Shift: Any

Employment Status: Regular - Full Time 


Seeking Breakthrough Makers   

Children’s Hospital of Philadelphia (CHOP)—named America’s 2022 Best Large Employer by Forbes—offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career. 


CHOP’s Commitment to Diversity, Equity, and Inclusion 

CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. 

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply. 

Job Summary

The Research Post-Doctoral Fellow will support basic science research projects within the Leukodystrophy Center at the Children's Hospital of Philadelphia. This is a a cutting-edge translational program that supports therapeutic development for a group of approximately 31 rare genetic disorders that affect development of the white matter of the brain, predominantly in pediatric populations. Current projects are focused on therapeutic development - using in vivo and in vitro models - for key leukodystrophyies such as Hypomyelination and Atrophy of Basal Ganglia and Cerebellum (H-ABC), Aicardi-Goutières Syndrome (AGS), and Alexander Disease.
The Leukodystrophy Center is currently seeking candidates for a post-doctoral position to focus on a research project involving development of novel therapeutic approaches using adeno-associated virus (AAV)-based gene therapy and antisense oligonucleotides (ASOs) in these target disorders. The position will include opportunities to participate in the design, optimization, and establishment of feasibility and safety of the proposed therapeutic approaches preparatory to clinical development. The laboratory, under the direction of Dr. Adeline Vanderver, MD, uses a variety of advanced scientific techniques, such as, stereotaxic surgery on rodents, induced pluripotent stem cell (iPSC) cultures, biomarker detection technology, spatial molecular profiling, etc. The post-doctoral fellowship includes participation in various training and career development programs to develop skills in key areas such as data management, biostatistics, manuscript preparation, etc. The post-doctoral fellow will receive direct mentorship from Dr. Vanderver and other senior scientists within the laboratory, tailed to training program within the lab will be individually tailored to prepare for their desired next career steps.
This position also involves external collaboration with other key leaders in the field of leukodystrophy. Dr. Vanderver is a co-founder of the Global Leukodystrophy Initiative Clinical Trials Network (GLIA-CTN), a Rare Diseases Clinical Research Network (RDCRN) consortium funded under grant number U54NS115052 in collaboration between the National Center for Advancing Translational Sciences (NCATS) and the National Institute of Neurological Disorders and Stroke (NINDS). The post-doctoral fellow will have opportunities to participate in grant-funded research collaborations, and attend/present at various scientific meetings and seminars.

The postdoctoral fellow will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project.  The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.  Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.  Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.




Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community.  As a condition of employment, professionals working onsite—at any CHOP location, for any portion of time—must be vaccinated for COVID-19. Learn more. 

CHOP also requires employees who work in patient care buildings to receive an annual influenza vaccine. Employees may request exemptions for valid religious and medical reasons.  Start dates may be delayed until candidates are immunized or exemption requests are reviewed.  

EEO / VEVRAA Federal Contractor        |              Tobacco Statement 


Nearest Major Market: Philadelphia

Job Segment: Neurology, Pediatric, Clinical Research, Medical Research, Healthcare, Research