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Research Postdoc Fellow - Center for Computational and Genomic Medicine

Philadelphia, PA, US, 19104

​Location: LOC_COLKET-Colket Translational Research 

Req ID: 210811

Shift: Any

Employment Status: Regular - Full Time 

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Job Summary

An NIH-sponsored postdoctoral fellow position is available in the Sgourakis lab at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (UPenn). Our Team investigates the molecular mechanisms of MHC-I antigen processing and presentation, including non-classical MHC molecules, toward clinical translation through the development of targeted therapeutics. For more information, visit www.sgourakislab.org

 

Multiple projects are available: (1) Mechanism-based understanding of ligand exchange on classical and nonclassical MHC-I molecules through structural biology studies of protein complexes with molecular chaperones; (2) Elucidating MHC-I recognition by peptide-centric Chimeric Antigen Receptors, toward the development of targeted cancer therapies; (3) Investigating the dynamic properties of pleiotropic cytokines, with the aim to design conformation-selective protein therapeutics.

 

Recent relevant publications: 

 

  1. TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nature Chemical Biology, 2022
  2. Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs. Nature, 2021
  3. Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. PNAS, 2020 
  4. Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. PNAS, 2019
  5. Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle. Nature Chemical Biology, 2018  

Job Summary (Continued)

Funding

The position is funded through an NIH-sponsored R01 project grant. A competitive salary and benefits package is offered through the CHOP research Institute.

  

Facilities

The Sgourakis lab has routine access to state-of-the-art facilities for biomolecular NMR and X-ray crystallography, which include cryoprobe-equipped 600 and 800 MHz AvanceNeo systems and an in-house crystal screening robot (Douglas instruments). Complementary biophysical assays run in our lab include a microcal VP-ITC instrument for isothermal titration calorimetry, a SpectraMax multi-mode microplate reader for various fluorescence-based detection assays, and a Biacore X100 instrument for Surface Plasmon Resonance biomolecular binding measurements. Additional facilities for AUC, protein crystallography are available the Johnson Foundation Structural Biology and Biophysics Core. High-field NMR access is provided through several instruments in the local NMR community.    

 

Applications should hold a Ph.D. in Molecular Immunology, Structural Biology, Biophysics, or a related discipline. Students who just received or are expected to receive their degree are encouraged to apply. Experience in either immunological assays, protein crystallography, NMR spectroscopy or protein engineering is desired. The position is available for immediate hire, with competitive salary & benefits package. To apply, please email a Cover letter and CV to: nikolaos.sgourakis@pennmedicine.upenn.edu

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Qualifications

  • The applicant will have rigorous training in the Rosetta protein modeling suite, and demonstrated experience in C++ code and protocol development.
  • Additional experience in working on unix shells, Python programming and high-performance computing is also viewed favorably. 
     

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

To carry out its mission, it is of critical importance for the Children’s Hospital of Philadelphia (CHOP) to keep our patients, families and workforce safe and healthy and to support the health of our global community. In keeping with this, CHOP has mandated all workforce members on site at any CHOP location for any portion of their time be vaccinated for COVID-19 as a condition of employment.  This mandate also applies to workforce members performing work for CHOP at non-CHOP locations. Additionally, all workforce members based in or regularly scheduled to work at any New Jersey location are mandated to be both vaccinated and boosted for COVID-19, with booster timing consistent with applicable guidelines. The CHOP COVID-19 vaccine mandate is in alignment with applicable local, state and federal mandates. CHOP also requires all workforce members who work in patient care buildings or who provide patient care to receive an annual influenza vaccine. Employees may request exemption consideration for CHOP vaccine requirements for valid religious and medical reasons.  Please note start dates may be delayed until candidates are fully immunized or valid exemption requests are reviewed. In addition, candidates other than those in positions with regularly scheduled hours in New Jersey, must attest to not using tobacco products.
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