Research Post Doctoral Fellow-The Sgourakis Lab

Philadelphia, PA, US, 19104

Job Type: 

Location: LOC_COLKET-Colket Translational Research 

Req ID: 84368

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

The Sgourakis Lab at the Children’s Hospital of Philadelphia is currently recruiting candidates for a post-doctoral research position.  Our NIH-funded research programs focus on mechanism-based studies of i) molecular chaperones involved in the folding, processing and peptide editing of MHC-I and MHC-II molecules and ii) T cell antigen receptor signaling complexes involved in cancer immunotherapy.  Our lab's principal efforts focus on mechanistic, structural and functional studies of protein complexes, with emphasis on the development of an iterative experimental / computational approach. To gain an atomic-detail description of these processes and to characterize novel therapeutic targets, we integrate cutting-edge structural biology methods from Nuclear Magnetic Resonance Spectroscopy, complementary biophysical and biochemical techniques, computational structure modeling with functional immunoassays. The group has regular access to a dedicated 600 MHz Bruker Neo NMR spectrometer, high-field instruments at local facilities, and outstanding X-ray crystallography and cryoEM facilities located at the UPenn campus. Our efforts are done in close collaboration with several groups within the vibrant structural biology, immunology and immuno-oncology communities at Children's Hospital of Philadelphia and the University of Pennsylvania.


  • Candidates should have a PhD in either a structural biology-related field, or in molecular immunology with a strong background in protein biochemistry. Excellent lab organization and team-oriented working skills are necessary for the position.
  • Successful candidates must be committed to working with diverse student populations. 




Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Job Responsibilities (Continued)

Job Responsibilities (Continued)

Required Licenses, Certifications, Registrations

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

Preferred Education, Experience & Cert/Lic

Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Talent Acquisition

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Philadelphia, PA 19146 




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