CHOP EMPLOYEE? SEARCH FOR JOBS HERE.

Research Post Doc-Kai Tan Laboratory

Philadelphia, PA, US, 19104

Job Type: 

COLKET - Colket Translational Research Req ID: 26856

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

A postdoctoral fellow position is open in the Tan research group in the Department of Pediatrics at the University of Pennsylvania and the Department of Biomedical and Health Informatics (DBHI) at the Children's Hospital of Philadelphia (CHOP).

The postdoctoral fellow will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project.  The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.  Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.  Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

More about the lab below: 

Kai Tan Laboratory

Led by Kai Tan, PhD, researchers in the Tan Laboratory are using systems biology approaches to identify and characterize gene pathways underpinning tumorigenesis and normal development. The ultimate goal of the research in this laboratory is to use information from patient-specific, integrated gene networks to improve the diagnosis and treatment of cancer patients.  

Ongoing research in the Tan Laboratory is focused on network modeling for tumorigenesis and discovery of new therapies. Results from these studies show that tumorigenesis and therapeutic responses involve dynamic changes in the molecular network of cancer cells. Using network-rewiring events can improve the accuracy of disease prognosis and offer new insights into gene pathways underlying disease progression. Additional studies are underway to comprehensively identify network-rewiring events in a range of pediatric tumors and use such information to improve prognosis and identify novel therapies.

Whole-genome sequencing has revealed a large number of DNA sequence mutations that are located in noncoding regions of the human genome. Researchers in the Tan Laboratory are developing a general computational framework for identifying noncoding genetic mutations that confer cancer risk. Understanding these mutations might unravel novel mechanisms underlying tumorigenesis and provide new tumor-specific targets.

Hematopoietic stem cells (HSCs) are routinely used in the treatment of hematopoietic malignancies. However their use in the clinic is limited by donor availability. Members of the Tan laboratory are combining genomic and computational approaches to better understand the gene regulatory circuitry underlying HSC development. Ultimately, this may lead to novel protocols for generating HSCs using a patient’s own cells.

 

 

Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Required Licenses, Certifications, Registrations
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288 

Email:TalentAcquisition@email.chop.edu

 

 

CHOP EMPLOYEE? SEARCH FOR JOBS HERE.


Nearest Major Market: Philadelphia

Job Segment: Medical, Patient Care, Medicare, Informatics, Healthcare, Research, Technology