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Research Post Doc Fellow- Virus-Host Interactions - Dr. Matthew Weitzman

Philadelphia, PA, US, 19104

​Location: LOC_COLKET-Colket Translational Research 

Req ID: 228371

Shift: Days

Employment Status: Regular - Full Time 

 

Seeking Breakthrough Makers   

Children’s Hospital of Philadelphia (CHOP)—named America’s 2022 Best Large Employer by Forbes—offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career. 

 

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CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children. 

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply. 

Job Summary

Our lab aims to understand host responses to virus infection and the cellular environment encountered and manipulated by viruses. We study multiple viruses in an integrated experimental approach that combines biochemistry, molecular biology, genetics and cell biology. Our research addresses fundamental questions of how viruses create conditions conducive to their own reproduction by shaping host cell environments, particularly with regards to genome interactions. We use viruses as model systems to study DNA repair, signaling, cell biology, replication, innate host defenses and gene delivery. We are particularly interested in recognition and processing of viral genomes by DNA repair pathways and how viruses overcome host restriction factors. We are using DNA virus systems to study signaling, ubiquitination and degradation, and transcriptional silencing. Viral model systems include adeno-associated virus (AAV), adenovirus (Ad) and herpes simplex virus (HSV). We have discovered cellular antiviral defenses, and identified viral strategies to manipulate these important host processes.

 

The successful applicant will become part of a highly interactive and collaborative team. Applicants must have a Doctoral degree in a related discipline with good skills in molecular biology, biochemistry and cell biology, and a strong motivation to learn new techniques and research topics. A background in virology and/or DNA repair would be advantageous. It is expected that this individual will conduct independent scholarly research, and will contribute to the overall research goals of the project and the research group. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows are also required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

 

Further details:

https://www.research.chop.edu/people/matthew-d-weitzman

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community.  As a condition of employment, professionals working onsite—at any CHOP location, for any portion of time—must be vaccinated for COVID-19. Learn more. 

CHOP also requires employees who work in patient care buildings to receive an annual influenza vaccine. Employees may request exemptions for valid religious and medical reasons.  Start dates may be delayed until candidates are immunized or exemption requests are reviewed.  

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