Research Lab Manager - Endocrinology and Diabetes-Roizen Laboratory

Philadelphia, PA, US, 19104

Job Type: 

Req ID: 25504

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

Roizen Laboratory  is seeking a full-time lab manager


The goal of the Roizen Laboratory is to understand the non-calciometabolic effects of vitamin D and to design new therapeutic approaches for common diseases like sarcopenia and obesity. Toward this goal the lab employs a uniquely diverse toolbox of methods, using large human data sets and mouse physiology combined with high-throughput sequencing to drive questions in cell culture, and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans.


Additionally, the Roizen Lab relies on core principles of improv to drive their science: listening, following the facts, finding what is interesting, being specific in scientific questions and hypotheses, and recognizing that for well-designed experiments there are no failures.


The Lab Manager is responsible for overall laboratory operations including daily workflow, quality control, management and supervision of staff and planning.


We are looking for someone who is expert in working with mice (including mouse genotyping) as well as cell biology/molecular biology. An ideal candidate is a self-starter who is comfortable working on their own or in a collaborative group, who is detail oriented/conscientious, curious, organized, hard working, flexible and able to work with individuals from a variety of backgrounds.


A typical day would start with a brief meeting with the PI to check in and then include maintenance of the mouse colony (weening and genotyping), cell culture work, several experiments (e.g. a western and a RT-RT-PCR and an elisa) and organizational work (ordering, following up on orders).


We do exciting, novel, clinically oriented translational research and look forward to working with you


Job Responsibilities

  • Proficiency in the use of a wide variety of lab techniques, research equipment and research related software
  • Plans projects, performs and directs daily laboratory work, analyzes results
  • In conjunction with Principle Investigator, modifies methods and protocols
  • Provides operational guidance over the laboratory and staff
  • Ensures staff adheres to maintains and implements department policies regarding procedures, objectives, safety etc.
  • Directs staff efforts in contributing to the strategic plan for the lab/center
  • Assists upper management in the development, implementation and evaluation of services, programs, protocols, and performance standards
  • Oversees  management of daily laboratory resource allocations; budget management
  • Supervises several junior technical staff

Identifies and interviews candidates for open positions


Project Highlights:

Vitamin D and muscle building: Vitamin D increases strength and muscle mass on a chow diet independent of its effects on calcium and phosphate metabolism. The Roizen Lab is using high-throughput sequencing to determine how vitamin D improves muscle function, as well as to identify other pathways that mimic vitamin D muscle effects.


Vitamin D and weight loss: Vitamin D specifically improves metabolism of fat and central sensing of fat. The team is using high-throughput sequencing to determine how vitamin D improves fat metabolism and central sensing of fat, as well as to identify other pathways that mimic vitamin D effects on fat metabolism and fat sensing.


Vitamin D and calorie allocation: Vitamin D specifically increases allocation of calories to fast-twitch muscle. Through high-throughput sequencing and CRISPR screening approaches, the lab is working to determine how vitamin D increases allocation of calories to fast-twitch muscle, and to identify other pathways that mimic these vitamin D effects.


Vitamin D as a tissue specific regulator of mitochondrial function: Vitamin D is a tissue specific regulator of mitochondrial oxidative phosphorylation capacity. Notably dietary vitamin D increases oxidative phosphorylation in fast-twitch muscle and the myocardium while it has no effect on it in slow-twitch muscle. We are using high-throughput sequencing to determine how these vitamin D effects are mediated as well as to identify other pathways that mimic these vitamin D effects.


Required Education and Experience

  • BS with 10+ years scientifically relevant experience required
  • MS with 6-8 years scientifically relevant experience required


Preferred Education, Experience & Cert/Lic

  • Terminal degree (MD, PhD, DVM) Post-Doctoral Fellow experience preferred, 2-4 years scientifically relevant post-fellowship experience

Additional Technical Requirements

  • 1-3 years staff management experience
  • 2-4 yrs. laboratory direction / management experience required

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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