Research Assoc II - Neuroblastoma Research- Yael P. Mossé Lab

Philadelphia, PA, US, 19104

Location: LOC_COLKET-Colket Translational Research 

Req ID: 128372

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

Seeking bright and motivated Research Associate to work under Yael P. Mossé, MD as part of a growing, multidisciplinary team that she oversees, focused on developing targeted and immune-therapies for childhood cancers. The ResearchAssociate will work as part of a highly collaborative team, both at Penn/CHOP and institutions across North America. Our research is focused on neuroblastoma, a common and often devastating childhood cancer of the peripheral nervous system. This position has two central projects, both focused on therapeutic targeting of the dominant oncogenes driving the growth of neuroblastoma: MYCN and ALK.
  • Amplification of the MYCN oncogene is present in over 40% of high-risk neuroblastomas, and many high-risk neuroblastomas without MYCN amplification show overexpressed MYC protein. Therapeutic targeting of MYC(N) proteins directly remains challenging. MYC family proteins are small basic helix-loop-helix transcription factors with an inherently unstructured N-terminus and no known binding pockets for small molecular interactions. That said, it is now clear that these proteins coordinate complex protein interactomes that likely vary by cellular, spatial and temporal contexts. Advances in structural biology and medicinal chemistry now allow an unprecedented opportunity to drug these previously undruggable oncoproteins. The objective of this multi-institution project is to develop drugs that will directly degrade and/or destabilize the MYCN oncoprotein in pediatric cancer models, and to provide preclinical proof-of-concept to bring these compounds to clinical trials.
  • Our discovery of gain-of-function mutations in ALK as the genetic etiology of familial NB provided the impetus for this second project. Moreover, these same mutations are the most frequent somatic single nucleotide mutation in this disease and have been shown to act as oncogenic drivers by promoting ligand-independent ALK tyrosine kinase activity. This project is focused on the development of highly specific antibody-based approaches to target cell surface anaplastic lymphoma kinase oncogene (ALK) on neuroblastomas and other ALK-expressing pediatric cancers.
These are both high-impact projects and there is the possibility of taking on one of the two proposed projects.

Job Responsibilities

  • Assists faculty in the conduct of research of significant value in the basic and/or translational science area
  • Plans, conducts, and manages research projects within the federal and institutional regulations and policies
  • Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives
  • Trains technical staff, students, fellows & physicians in lab procedures
  • Reviews manuscripts for peer-reviewed journals
  • Assist in composing/developing applications for grants/contracts for funding of research projects
  • Promotes free discussion, research progress, and overall morale
  • Responsible for appropriate use of research funds
  • May supervises staff and students

Job Responsibilities (Continued)

Job Responsibilities (Continued)

Required Licenses, Certifications, Registrations


Required Education and Experience

  • Master’s degree, 5-7 years of scientifically relevant experience required
  • Bachelor’s degree 10+ years of scientifically relevant experience required


Preferred Education, Experience & Cert/Lic

Terminal degree (MD, PhD, DVM) preferred, 2 or more years Post-Doctoral fellowship experience; 1-3 years scientifically relevant experience

Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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