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Research Assoc I - Division of Human Genetics- Gene Therapy

Philadelphia, PA, US, 19104

​Location: LOC_MAIN-Main Hospital 

Req ID: 172357

Shift: Any

Employment Status: Regular - Full Time 

​About Us
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Job Summary

A Research Associate position is available in the laboratory of  Ahrens-Nicklas Laboratory within the Division of Human Genetics at the Children’s Hospital of Philadelphia.
Our lab investigates inherited biochemical disorders both to answer fundamental biologic questions and to develop new therapies for these devastating diseases.  We are looking for curious, motivated, talented individuals to join our group.
While individually rare, inherited biochemical disorders (i.e. inborn errors of metabolism, IEMs) occur in approximately 1/1,500 births. The vast majority of patients have neurologic and/or cardiac symptoms that do not respond to therapy, even if a treatment can improve biochemical markers of disease in blood. Using genetic, biochemical, and electrophysiologic techniques in cells, model organisms, and human subjects, we investigate the mechanisms that drive neurologic and cardiac dysfunction in patients with IEMs. We also evaluate the efficacy of new therapeutic strategies for IEMs (including small-molecule, network-directed, and gene therapies). We hypothesize that genetic defects in biochemical pathways alter the development and evolution of electrical circuits in excitable tissues. To improve outcomes in patients, therapies will have to correct both the biochemical defect and the secondary circuit-level pathology that directly drives patients’ symptoms.
 
 
 Please send cover letter and CV to AhrensNicklasR@chop.edu

Current Projects:

Currently available projects include:
  • Evaluation of new therapies for neuronopathic lysosomal storage diseases using in vivo electrophysiology, in vitro advanced imaging techniques in mouse models, and biochemical assays in patient-derived induced pluripotent stem cells (iPSCs).
  • Characterization of new mouse models of inherited metabolic disorders using metabolomic, behavioral, and electrophysiologic techniques.
 

Job Responsibilities

  • Assists faculty in the conduct of research of significant value in the basic and/or translational science area
  • Plans, conducts research projects within the federal, institutional regulations and policies
  • Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives
  • Trains technical staff, students in lab procedures
  • Reviews manuscripts for peer-reviewed journals
  • Assists with the submission of grant applications, contracts and research projects funding
  • Participates in free discussion, research progress, and overall morale
  • Responsible for appropriate use of research funds
  • May supervise students

Job Responsibilities (Continued)

Required Licenses, Certifications, Registrations

None

Required Education and Experience

Required Education: Bachelor’s degree


Required Experience: One (1) year of scientifically relevant experience

Preferred Education, Experience & Cert/Lic

Preferred Experience: 

  • Terminal degree (MD, PhD, DVM) with one (1) year Post-Doctoral fellowship experience OR
  • Master’s degree, three (3) or more years of scientifically relevant experience OR
  • Bachelor’s degree, seven (7) or more years of scientifically relevant experience

Additional Technical Requirements

To carry out its mission, it is of critical importance for the Children’s Hospital of Philadelphia (CHOP) to keep our patients, families and workforce safe and healthy and to support the health of our global community. In keeping with this, CHOP has mandated all workforce members on site at any CHOP location for any portion of their time be vaccinated for COVID-19 as a condition of employment.  This mandate also applies to workforce members performing work for CHOP at non-CHOP locations. Additionally, all workforce members based in or regularly scheduled to work at any New Jersey location are mandated to be both vaccinated and boosted for COVID-19, with booster timing consistent with applicable guidelines. The CHOP COVID-19 vaccine mandate is in alignment with applicable local, state and federal mandates. CHOP also requires all workforce members who work in patient care buildings or who provide patient care to receive an annual influenza vaccine. Employees may request exemption consideration for CHOP vaccine requirements for valid religious and medical reasons.  Please note start dates may be delayed until candidates are fully immunized or valid exemption requests are reviewed. In addition, candidates other than those in positions with regularly scheduled hours in New Jersey, must attest to not using tobacco products.
EEO / VEVRAA Federal Contractor

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