Research Assoc I - Cell Pathology- Argon Lab

Philadelphia, PA, US, 19104

Req ID: 116509

Recruiter: Heather Warman 

Shift: Days

Employment Status: Regular - Full Time 

Salary Grade: S 15 

For more information about CHOP's current Fiscal Year Compensation Plan Guidelines please click here

Job Summary

Research in the Argon Lab focuses on the role of unfolded protein response (UPR) in combating diseases, such as diabetes and growth retardation. Much of the lab’s research program concerned the control of protein folding in the ER by molecular chaperone and the challenge of quality control of the secretory proteome. The Argon Lab characterized the role of BiP in the normal folding and assembly of immunoglobulin, and how it distinguishes properly folded from misfolded proteins, which are destined for destruction.

The lab team discovered that GRP94, a distinct ER chaperone, is essential for production of antibodies and that it operates with BiP in sequential manner. Both chaperones are hallmarks of the UPR and are also involved in the triage of improperly folded secretory proteins to degradation. The lab investigated the ubiquitin/proteasome pathway of disposal.

More recently, the Argon Lab studied the impact of limiting chaperones and folding enzymes on the protein-folding environment and showed that there are distinct forms of UPR, depending on the type of folding stresses. This led to the discovery of a protein disulfide isomerase whose main function is to interact with and limit the activation of the IRE1 sensor of the UPR, thus guarding against an excessive response that would be detrimental to the cell. This rheostat-like action is due to two distinct enzymatic activities of the IRE1 sensor, that come into play under different times and distinct conditions and underlie the distinct types of UPR seen in various diseases.

Currently the Argon Lab visualizes the dynamics of the IRE1 sensor by live cell imaging as it responds to differentiation signals and to various degrees of stress.

Job Responsibilities

  • Assists faculty in the conduct of research of significant value in the basic and/or translational science area
  • Plans, conducts research projects within the federal and institutional regulations and policies
  • Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives
  • Trains technical staff, students in lab procedures
  • Reviews manuscripts for peer-reviewed journals
  • Assists with the submission of grant applications/contracts and funding of research projects
  • Participates in free discussion, research progress, and overall morale
  • Responsible for appropriate use of research funds
  • May supervise students

Required Licenses, Certifications, Registrations


Required Education and Experience

  • Terminal degree (MD, PhD, DVM),  1or more years Post-Doctoral fellowship experience
  • Master’s degree, 3-5 years of scientifically relevant experience required
  • Bachelor’s degree, 7+ years of scientifically relevant experience required

Preferred Education, Experience & Cert/Lic

Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Philadelphia, PA 19146 




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