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Res Post Doc Fellow -Pediatric oncology genomics and immunotherapy translational research

Philadelphia, PA, US, 19104

Job Type: 

COLKET - Colket Translational Research Req ID: 27681

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, DVM, etc. and will conduct translational pediatric cancer biology, genomics and immuno-oncology research under the direction/guidance of Dr. Kris Bosse at the Children’s Hospital of Philadelphia (CHOP) and University of Pennsylvania (UPenn). Dr. Bosse’s laboratory is focused on understanding the underlying molecular mechanisms driving neuroblastoma tumorigenesis and developing new therapies, including immunotherapeutic strategies, for this and other aggressive pediatric cancers (see Bosse et al., 2017 Cancer Cell as an example). The postdoc will join a growing translational research team based in his laboratory. Several opportunities are available to explore and define the underlying mechanisms of therapeutic resistance and disease progression in neuroblastoma utilizing data acquired from the serial profiling of circulating tumor DNA (ctDNA) in this disease.  Key putative genomic mechanisms of therapeutic resistance have been identified that are primed for functional validation studies using CRISPR-based approaches. Other opportunities exist to work in collaboration with several other laboratories at CHOP/UPenn and at 10 other institutions as part of the St. Baldricks-Stand Up To Cancer Immunogenomics Team in developing and validating new immunotherapeutic strategies for pediatric cancers. Multiple specific projects exist under this umbrella also, designed to discover and develop novel, impactful new immune-based therapies for children with cancer. Available projects include translating current immunotherapies in the lab across pediatric cancers, new immunotherapeutic target discovery in neuroblastoma and other pediatric cancers, chimeric antigen receptor T cell therapy and antibody-drug conjugate development, defining mechanisms of tumor cell intrinsic and extrinsic immune escape and deciphering the key biologic functions of prioritized immunotherapeutic targets. Cancer and molecular biology experience is required, and familiarity with advanced genomic and immuno-oncology techniques and methods are preferred skills. This job is open to those seeking first or second post-docs. 
 
 

Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288 

Email:TalentAcquisition@email.chop.edu

 

 

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