Res Post Doc Fellow

Philadelphia, PA, US, 19104

Job Type: 

ROBERTS - Roberts Ctr Pediatric Research Req ID: 28507

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary

The Bioinformatics Team within the Center for Data-Driven Discovery in Biomedicine (D3b - at the Children’s Hospital of Philadelphia (CHOP) is seeking a talented postdoctoral fellow to carry out a mentored, bioinformatics (computational) research project within the field of oncology, focused on the discovery of novel oncogenic mechanisms of pediatric brain tumors. This candidate will have a terminal degree PhD, MD, DVM, etc. and will assume responsibility for a specific, on-going research project under the direction/guidance of Dr. Jo Lynne Rokita (within the D3b center led by Drs. Adam Resnick and Phillip B. Storm). The postdoctoral fellow will generate hypotheses and utilize and integrate WGS, RNA-Seq, and potentially extend analyses to include miRNA-Seq, methylation arrays, single-cell RNA-Seq, proteomics, and/or drug screen data. Current research projects in the group include: characterization of pediatric brain tumors with alternative lengthening of telomeres (ALT), identification and characterization of predisposing copy number/structural alterations in high-grade astrocytic tumors, genomic characterization of brain tumor models, and gene fusion annotation and prioritization.

The postdoc experience will serve to extend, refine, and enhance the skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, neat code documentation, code review, rigorous interpretation/evaluation of data, and dissemination of results. Postdocs will also be expected to acquire additional technical expertise, manuscript/grant writing skills, and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows may be required to supervise junior team members, develop new bioinformatics methods for research, and assist with the development of other research projects in the center. CHOP postdoctoral fellows are also enrolled in the University of Pennsylvania’s Biomedical Postdoctoral Program with ample opportunities for career development seminars, mentorship opportunities, and additional training in leadership and responsible conduct of research.                                                                                                                                                           

Job Responsibilities

Data Analysis (40%): Analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data primarily independently, with mentorship from the Principal Investigator
·       Develop robust hypotheses and analysis plans for an independent research project. 
·       Incorporate novel and advanced applications and methods into analysis.

Collaboration (30%): Establish a collaborative role within D3b and externally.
 ·    Regularly meet with the Principal Investigator about project-specific goals and analyses.
 ·    Contribute to daily stand-up meetings and weekly lab and bioinformatics scientific meetings with the bioinformatics team.
·       Define and promote boundaries of support by assessing all stakeholders, including bioinformatics management, collaborator expectations, and funding levels and mechanisms.
·       Develop new collaborations with low degree of supervision.

Academic Output (30%): Develop presentations, grants, and manuscripts with subsequent review by peers and mentors.
·       Present research findings at relevant conferences.
·       Lead bioinformatics-focused manuscripts and publications.
·       Seek and apply for relevant grant-funding mechanisms, such as NIH K99/R00, Alex’s Lemonade Stand Young Investigator Grant, Rally Foundation Fellowship Grant, Department of Defense Postdoctoral Grants.
·       Contribute to bioinformatics sections of grant and award proposals.

Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Additional Technical Requirements

·       Experience in applied bioinformatics, genomics, and computational work.
·       Experience with management and analysis of complex data types.
·       Experience with genomic and/or proteomic data analysis methods.
·       Strong UNIX/LINUX expertise required.
·       Fluency in two or more of: R, Python, Perl, bash, high-performance cluster computing, and/or cloud computing.
·       Experience with pipeline or workflow development frameworks.
·       Experience or knowledge of array/sequencing technologies commonly used in biological labs, such as RNA-Seq, WGS, WES, miRNA-Seq, SNP arrays, single cell sequencing, proteomics, as well as applicability to a specific biological problem is preferred..
·       Proficiency in various open source and commercial bioinformatics resources and software required.
·       Strong knowledge of, and experience with, cancer genomics bioinformatics applications and research preferred.
·       Familiarity with resources of genomic data sets and analysis tools, such as TCGA, TARGET, UCSC Genome Browser, Bioconductor, ENCODE, and NCBI databases is required.
·       Ability to correctly select and perform statistical tests for most types of genomic data, and to properly interpret their results in the scenario of a specific study is preferred.
·       Ability to interact with biologists and clinicians during a scientific discussion is required.
·       Accountability and attention to timelines.
·       Excellent organization and communication skills with an emphasis on strong presentation skills.
·       Ability to independently plan and execute analyses of high complexity required.
·       Ability to provide objective validation of results required.
·       Ability to work in a team environment.

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288




Nearest Major Market: Philadelphia

Job Segment: Oncology, Medical, Patient Care, Cloud, Healthcare, Technology, Research