Res Post Doc Fellow - Lung Development and Regeneration

Philadelphia, PA, US, 19104

Location: LOC_ABRAMSON-Abramson Building 

Req ID: 150992

Shift: Any

Employment Status: Regular - Full Time 

Job Summary

The Zepp Lab, of the University of Pennsylvania and Children’s Hospital of Philadelphia, is looking for a Post-Doctoral scientist to join our growing group. Our lab seeks to understand the cellular and molecular mechanisms underlying lung diseases in children and adults.  We have several lines of investigation focused on the functions of lung fibroblast lineages. We are looking for creative scientists to help us build new models to parse the varied functional responses of unique fibroblast subsets and how they contribute to disease. Our lab takes a comprehensive approach that includes genetic mouse models, three-dimensional in vitro cell culture, live imaging, molecular and transcriptomic profiling to interrogate these cellular processes. 

In close collaboration with Dr. Zepp and other members of his lab, the Post-Doctoral fellow will take the lead on research projects of their choosing. Projects may include (a) investigating transcriptional and epigenetic regulators of fibroblast identity in the lung and their contribution to lung regeneration. (b) Identifying the mechanisms of fibroblast activation states and their impact on local immunity. (c) Testing how direct cell-cell interactions between fibroblast subsets and the microvasculature contribute to lung repair after respiratory viral infection. All of these studies would incorporate cutting edge techniques such as single-cell sequencing and novel mouse models to map the lineage paths and molecular signatures in subsets of fibroblasts. Further, we are translating these findings through the use of primary pediatric and adult cells obtained through our Penn-CHOP Lung Biology Institute. These projects are currently supported by the NIH and foundation grants.
The ideal candidate is enthusiastic, promotes a scholarly environment and is highly creative. Our lab works collaboratively with other Pulmonary investigators at CHOP. Together our labs and our trainees have unlimited access to designated resources for histology processing (paraffin, IHC and vibratome sectioning), single-cell sequencing and advanced imaging (fluorescence, live-imaging and confocal).
Applicants must have a doctoral degree in a relevant field, such as Biology, Biochemistry, Cellular and/or Developmental Biology, Physiology, Bioengineering or Pharmacology and a strong background in techniques relevant to these fields.
For more information about us and our science please visit our site: thezepplab.com

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Job Responsibilities (Continued)

Job Responsibilities (Continued)

Required Licenses, Certifications, Registrations

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

Preferred Education, Experience & Cert/Lic

Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Philadelphia, PA 19146 




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