Res Post Doc Fellow-Genomics of Endocrine Traits

Philadelphia, PA, US, 19104

Location: LOC_ABRAMSON-Abramson Building 

Req ID: 90534

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

 A Postdoctoral Fellow is needed to join a dynamic group of investigators interested in studying the functional consequences of signals that have come out of recent genome wide association studies (GWAS) of endocrine traits, including childhood obesity, bone mineral density and diabetes. The successful candidate will be dedicated and motivated, and a driver of her/his research. The postdoctoral fellow will be responsible of setting up disease models in human cell lines and iPSC-derived cells, characterize their trait-related phenotypes and manipulate candidate gene expression using CRISPR/Cas9 and/or siRNA or gene overexpression, with the goal of validating novel disease target genes. We are looking for a candidate with strong molecular biology skills (immunofluorescence, Western Blot, PCR, cloning) and prior experience in either endocrine cellular models or iPSC-derived cell biology. In addition, experience in CRISPR/Cas9 genome editing and next-generation sequencing based techniques (RNA-seq, ATAC-seq, ChIP-seq) would be a plus.

Job responsibilities include:

1. To lead specific projects agreed upon with the P.I.

2. Perform calculations and maintain appropriate log books and lab notebooks.

3. Analyze and interpret resulting data.

4. Submit findings in peer-review journals and present at national and international meetings.


Preferred aplicant will have:


A terminal degree PhD, MD, DVM with a major in biology, chemistry, biochemistry or related field preferred. Excellent communication, organizational and molecular biology skills are a must, together with previous experience either in cellular models relevant to endocrinology or iPSC-derived cells. Hands-on experience with CRISPR/Cas9 genome editing and next-generation sequencing based techniques (such as RNA-seq, ATAC-seq, ChIP-seq) would be a plus


Interested individuals should submit their resume to or Struan Grant, Ph.D., Abramson Research Center, The Children's Hospital of Philadelphia, Room 1216F, 3615 Civic Center Blvd., Philadelphia, PA 19104,

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Required Licenses, Certifications, Registrations

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

Preferred Education, Experience & Cert/Lic

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

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Talent Acquisition

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Philadelphia, PA 19146 




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