Res Post Doc Fellow - Dr. Mosse's lab

Philadelphia, PA, US, 19104

Job Type: 

LOC_COLKET-Colket Translational Research Req ID: 82132

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

Seeking creative and motivated postdoctoral fellow to work under Dr. Yael Mossé as part of a growing, multidisciplinary team that he oversees, focused on developing immunotherapies for childhood cancers. The postdoc will work as part of a highly collaborative team, both at Penn/CHOP and institutions across North America.

Our research is focused on neuroblastoma, a common and often devastating childhood cancer of the peripheral nervous system.  This project is focused on the development of highly specific antibody-based approaches to target cell surface anaplastic lymphoma kinase oncogene (ALK) on neuroblastomas and other ALK-expressing pediatric cancers.

Our discovery of gain-of-function mutations in ALK as the genetic etiology of familial NB provided the impetus for this project. Moreover, these same mutations are the most frequent somatic single nucleotide mutation in this disease and have been shown to act as oncogenic drivers by promoting ligand-independent ALK tyrosine kinase activity. These findings position ALK as the only mutated oncogene tractable for targeted therapy in NB. Our studies have revealed that native ALK protein is expressed on the surface of the majority of NB cells, but not on normal tissue, providing an opportunity for development of immune targeting strategies. The rationale for this funded research is that optimizing strategies for effective ALK kinase and cell surface ALK inhibition to achieve durable therapeutic responses will dramatically impact cure rates not only in NB, but perhaps also in other cancers in which ALK has been shown to be a major oncogenic driver. Our lab is uniquely situated to translate this discovery into the identification of rational and targeted therapeutic approaches for patients with highly malignant neuroblastoma.

The postdoc will have the opportunity to work to develop an independent project as well as work on several collaborative projects, benefiting from access to a broad range of patient samples and datasets (genomic, transcriptomic, proteomic, etc.).

This job is open to those seeking first or second post-docs. Preference also given to post-docs eligible for K99/R00 awards and those seeking future independent academic careers

Job Responsibilities

  1. Conduct independent research and develop new methods and projects.
  2. Participate in project planning, recording and evaluation of data.
  3. Acquire technical, lab management and grant writing skills.
  4. Participate in seminars, lectures, poster sessions and presentations at meetings/conferences.
  5. Supervise junior lab members.
Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Job Responsibilities (Continued)
Job Responsibilities (Continued)
Required Licenses, Certifications, Registrations
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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