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Res Post Doc Fellow -Dr. Bosse's laboratory-Pediatric Oncology Genomics & Immunotherapy Research

Philadelphia, PA, US, 19104

Job Summary

The cure rate for children with neuroblastoma is unacceptable, making the development of new therapies imperative. The Bosse Lab is seeking a Research Post Doc Fellow to assist in discovering and developing new neuroblastoma cell surface immunotherapeutic targets. The lab aims to capitalize on the robust differential expression of these molecules with immune-based therapeutics with a goal to translate new transformative drugs to the clinic and study the underlying biology of these molecules to improve the understanding of the critical biologic mechanisms driving neuroblastoma tumorigenesis.

For example, the lab has discovered that the lineage-restricted oncoprotein, glypican-2 (GPC2), is robustly and selectively expressed on the surface of neuroblastomas and that this molecule is essential to neuroblastoma tumorigenesis. The lab is now focused on defining the underlying biology of neuroblastoma’s dependence on GPC2 and developing immunotherapeutic approaches targeting GPC2, including antibody-drug conjugates and chimeric antigen receptor (CAR) T cells. Furthermore, using its immunotherapeutic target discovery algorithm and validation platform, the lab is also developing additional differentially expressed neuroblastoma cell surface molecules for immune-based therapies. This work is done as part of the St. Baldrick’s Foundation-SU2C Pediatric Cancer Dream Team.

Another project in the lab centers on the serial sequencing of circulating tumor (ctDNA) from neuroblastoma patients to define tumor heterogeneity and clonal evolution while children are receiving both conventional chemoradiotherapies and more targeted therapeutics. The team anticipates these efforts may help define a role for ctDNA profiling in the clinical care of children with neuroblastoma and other pediatric solid tumors and also identify novel mutated driver oncogenes that warrant additional functional validation.

Finally, the laboratory is also interested in defining the functional implications of neuroblastoma-associated germline genetic variation, with a particular interest in describing the role of common and rare genetic variation in the regulation of BARD1 gene expression and splicing and how these alterations collectively contribute to neuroblastoma predisposition.

The postdoctoral fellow will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project.  The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.  Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.  Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

 

 

 

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Required Licenses, Certifications, Registrations

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

Preferred Education, Experience & Cert/Lic

Additional Technical Requirements

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