Res Post Doc Fellow - Dr. Bhoj's lab

Philadelphia, PA, US, 19104

Job Type: 

LOC_ABRAMSON-Abramson Building Req ID: 72841

Shift: Any

Employment Status: Regular - Full Time 

Job Summary

The motivation behind the work of the Bhoj lab-  Bhoj Lab is to provide answers to families about their child’s medical issues and work towards targeted therapies for genetic disorders. There are many thousands of children who are suspected to have a genetic disorder, but remain without a diagnosis, even after expert evaluation. Many of these children have yet-undiscovered genetic syndromes, and the Bhoj lab uses advanced sequencing technology to identify these novel syndromes. Two of the syndromes we now focus on are caused by disruption of Histone 3.3 (H3F3A and H3F3B) and TBC1 domain-containing Kinase (TBCK).

Histone 3.3 is one of the replacement histones, and is vital for appropriate cell division, transcription, and many other processes. Somatic variants cause a variety of cancer, including pediatric glioblastoma. Our laboratory described a pediatric neurodegenerative condition caused by germline variants in H3F3A and H3F3B, which both code for the Histone 3.3 protein. Using patient cells, mouse models, and iPSC cells, we are learning more about why these genetic variant cause this disease. Our goal is to be able to learn enough about the pathogenesis of the disorder to develop the first targeted therapies for this progressive neurologic disorder.

Our laboratory was also instrumental in the discovery of TBC1 domain-containing Kinase (TBCK) as a cause of progressive neurodegeneration in children. Very little was known about the role of TBCK, and we are working to learn more about how TBCK works in healthy tissues and contributes to neurodegeneration. We are using patient cells and model organisms to understand how the loss of this protein disrupts normal neurologic development. Our early data suggested the mTOR pathway was downregulated in these patients, and we showed that leucine, an amino acid, is a potential targeted therapy. We are now working on leucine and related compounds in animal models of the disease and hope to start a human trial. more information Bhoj Lab



Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Job Responsibilities (Continued)
Job Responsibilities (Continued)
Required Licenses, Certifications, Registrations
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Philadelphia, PA 19146 




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