Res Post Doc Fellow -CRISPR/Cas9 Screens-Hematopoietic Stem Cells

Philadelphia, PA, US, 19104

Job Type: 

LOC_ABRAMSON-Abramson Building Req ID: 45361

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

A postdoctoral fellow position is available at The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, to perform state-of-the-art CRISPR/Cas9 screens to identify novel regulators of hematopoietic stem cells as well as leukemias. B-acute lymphoblastic leukemia (B-ALL) is the leading cause of cancer-related death in young people and commonly has poor outcomes in adults. This postdoctoral fellow position focuses on investigating mechanisms underlying high risk ALL using our novel B-ALL mouse models that are highly relevant to human precursor B-ALLs. CRISPR screens with our expert collaborators will delineate a new understanding of B-ALL development and point to potentially druggable pathways for intervention. Furthermore, we will also aim to identify genes whose loss-of-function confer resistance to current ineffective therapies.

You can find our recent publication in below website.


Candidates should have a Ph.D. or equivalent degree and experience with investigating biochemistry, cell biology, molecular biology, as well as mouse models.

Highly motivated candidates with good publication record are encouraged to apply. Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to: tongw@email.chop.edu

Wei Tong, PhD

Associate Professor of Pediatrics,

Children's Hospital of Philadelphia,

Perelman School of Medicine at the University of Pennsylvania,

Co-Director, Hematopoietic Stem Cell program,

Institute for Regenerative Medicine at UPENN

Abramson Bldg. 310D,

3615 Civic Center Blvd.,

Philadelphia, PA 19104

(O) 267-426-0930

Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Job Responsibilities (Continued)

The postdoctoral fellow will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project.  The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.  Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.  Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

Job Responsibilities (Continued)
Required Licenses, Certifications, Registrations
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

VEVRAA Federal Contractor/Seeking priority referrals for protected veterans.  Please contact our hiring official with any referrals or questions.

CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288 





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