Postdoctoral Research Fellow in Single-cell Computational Epigenetics - Zhou Lab

Philadelphia, PA, US, 19104

​Location: LOC_COLKET-Colket Translational Research 

Req ID: 210801

Shift: Any

Employment Status: Regular - Full Time 

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Job Summary

The Zhou lab at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania is looking for a motivated post-doctoral researcher to work on the topic of Single-cell Computational Epigenetics. The lab is based in the new Center for Computational and Genomic Medicine at CHOP. The positions will be inside the laboratory of Wanding Zhou, a new investigator having worked in the field of computational epigenetics, organismal development and informatics for analyzing high-throughput multi-omics data. The planned project aims at developing computational methods to uncover the dynamics of epigenetics and the biology of gene regulation in single cells. The recruit will use a wide-range of big data analytics to tackle human medical applications including liquid-biopsy and cell identity tracing.


When hired, the recruit will work closely with the Dr. Zhou and other faculty members in the center to conduct original high-caliber research. The recruit is also encouraged to initiate and lead collaborative work with other PIs at CHOP and UPenn or as part of genomics data consortia. Salary will be commensurate with qualification and increase with experience.



1. develop software to study epigenetics and gene regulation in human.

2. conduct computational analysis of high-throughput epigenetic data (single-cell methylome sequencing, ATAC-seq etc).

3. harmonize and integrate a sizable volume of public data.

4. evaluate existing computational methods

5. author peer-review research papers.


Qualified candidates should be proficient in computer programming (e.g., via R, Bash etc) and should have experience in the interpretation and execution of computational analysis of genomics data. He or she should hold or expect at the time of hire, a Ph.D. or D.Sc. degree in a related field (e.g., Genomics, Bioinformatics, Computer Science, Computational Biology, Bioengineering, etc.). Knowledge of genetics and epigenetics, and single-cell biology is a plus.

Please send your application to Dr. Wanding Zhou at Your application should include a cover letter summarizing your interests, expertise, and research goals and a CV containing prior and ongoing publication and contact information for three references. More info can be found on our website at

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

To carry out its mission, it is of critical importance for the Children’s Hospital of Philadelphia (CHOP) to keep our patients, families and workforce safe and healthy and to support the health of our global community. In keeping with this, CHOP has mandated all workforce members on site at any CHOP location for any portion of their time be vaccinated for COVID-19 as a condition of employment.  This mandate also applies to workforce members performing work for CHOP at non-CHOP locations. Additionally, all workforce members based in or regularly scheduled to work at any New Jersey location are mandated to be both vaccinated and boosted for COVID-19, with booster timing consistent with applicable guidelines. The CHOP COVID-19 vaccine mandate is in alignment with applicable local, state and federal mandates. CHOP also requires all workforce members who work in patient care buildings or who provide patient care to receive an annual influenza vaccine. Employees may request exemption consideration for CHOP vaccine requirements for valid religious and medical reasons.  Please note start dates may be delayed until candidates are fully immunized or valid exemption requests are reviewed. In addition, candidates other than those in positions with regularly scheduled hours in New Jersey, must attest to not using tobacco products.
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