Clinical Genomic Scientist I - Cancer R&D

Philadelphia, PA, US, 19104

Location: LOC_ABRAMSON-Abramson Building 

Req ID: 134517

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

The Division of Genomic Diagnostics at the Children’s Hospital of Philadelphia is seeking a highly motivated scientist to join our CAP/CLIA-certified Genomic Diagnostic Laboratory to support the test development efforts for the expanding cancer diagnostics program. The ideal candidate will have a solid background in molecular biology and genetics, strong analytic and problem solving skills, and in-depth understanding of advanced genomic technologies including Next Generation sequencing (NGS) used in diagnostics and precision medicine. 

Job Responsibilities (Continued)

Responsibilities include but are not limited to:

  • Support the lab’s efforts to develop nucleic-acid based cancer genomic tests such as whole exome sequencing, transcriptome sequencing (RNA-Seq), whole genome sequencing, and liquid biopsy.
  • Design and conduct validation experiments, analyzes validation data, and write detailed and accurate standard operation protocols and high quality validation reports
  • Define quantitative metrics and thresholds for quality control and establish quality assurance program for the newly developed tests.
  • Train clinical staff and transition developed tests from the R&D phase to the clinical testing phase
  • Identify and troubleshoot technical and data analysis problems proactively and independently
  • Present results at group and external meetings and assist with preparing manuscripts as needed

Required Education and Experience

Required Education:  Master’s Degree in Genetics, Molecular Biology or related field


Required Experience: At least three (3) years of relevant experience.

Preferred Education, Experience & Cert/Lic

Preferred Education:  Ph.D. in Genetics, Molecular Biology or related field.


Preferred Experience: Clinical laboratory or research experience in a disease area, genetic pathway or genomic testing technology

Additional Technical Requirements

  • Advanced analytic skills required, preferably demonstrated by peer-reviewed publications
  • High level accountability and attention to details required
  • Clinical laboratory or research experience in a disease area, genetic pathway or genomic testing technology preferred
  • Excellent organization and communication skills required
  • Ability to work independently and in a team environment required
  • Knowledge of the working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies preferred.
  • Familiarity with resources of genomic data sets and analysis tools, such as UCSC Genome Browser, HGMD, ClinVar, Alamut and NCBI databases preferred.

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 




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